Lack of which vitamin is associated with Pellagra?

Pellagra is a condition that arises due to a deficiency of niacin, which is also known as vitamin B3. Niacin plays a crucial role in energy metabolism and the synthesis of certain coenzymes in the body, which are essential for various metabolic processes. The hallmark symptoms of Pellagra include dermatitis, diarrhea, and dementia, collectively referred to as the "three Ds."

When there is an insufficient intake of niacin, or when it cannot be adequately converted from its precursor tryptophan due to dietary deficiencies or other metabolic issues, the body exhibits these symptoms. This highlights the importance of niacin in maintaining overall skin, digestive, and neurological health.

The other options listed—vitamin B12, thiamine, and vitamin C—are associated with different conditions. Vitamin B12 deficiency, for instance, is linked to pernicious anemia and neurological issues, while thiamine is crucial for carbohydrate metabolism and its deficiency leads to beriberi. Vitamin C is essential for collagen production and its deficiency results in scurvy. Each of these vitamins has specific roles and deficiencies lead to distinct health issues, making niacin’s link to Pellagra particularly unique and significant.